Table 2.
Published clinical studies using CAR-T cells for treating solid tumors
| Targeted antigen | Disease | Vector | CAR generation | Sponsor | NCT identifier | Reference |
|---|---|---|---|---|---|---|
| FRa | Ovarian cancer | Retrovirus | First | National Cancer Institute | NA | 29 |
| Mesothelin | Pancreatic cancer | mRNA | Second | University of Pennsylvania | NA | 388 |
| c-MET | Breast cancer | mRNA | Second | University of Pennsylvania | NCT01837602 | 389 |
| EGFRvIII | Glioblastoma | Lentiviral | Second | University of Pennsylvania | NCT02209376 | 390 |
| CEACAM5 | CRC | Retrovirus | First | The University of Manchester | NCT01212887 | 391 |
| CEA | CRC | Lentivirus | Second | Third Military Medical University | NCT02349724 | 175 |
| HER2 | Glioblastoma | Second | Baylor College of Medicine | NCT01109095 | 189 | |
| GD2 | Neuroblastoma | Retrovirus | First | Baylor College of Medicine | NCT00085930 | 392 |
| CD133 | HCC, CRC, pancreatic cancer | Lentivirus | Second | Chinese PLA General Hospital | NCT02541370 | 393–395 |
NA not available