Fig. 7.

Chitosan-coated PLGA NPs show increased size, zeta potential, and cellular uptake by human airway epithelial cells. a SEM image of chitosan-coated PLGA NPs. b Percentage cumulative CaMKIIN release from PLGA NPs. c Determination of size and zeta potential in chitosan-coated and uncoated PLGA NPs. d Cellular uptake of CaMKIIN in HAECs cells using control (cells alone in culture media), uncoated and chitosan-coated PLGA NPs (*P ≤ 0.05, **P < 0.01, ****P < 0.0001). e Schematic presentation of chitosan-coated PLGA NPs in lung. f Images of control (saline) and uncoated and coated PLGA NPs loaded with fluorescent dye in various organs (lungs, heart, liver, stomach, kidney) at 1, 24, and 48 h after oral administration. Reproduced from ref. ¹⁷⁵