Table 3. Co-sibling analyses for gestational age at birth in relation to risk of lipid disorders, Sweden, 1973–2016.
Gestational age at birth | Cases | Ratea' | Adjusted for shared familial factorsb | Additionally adjusted for child and maternal characteristicsc | ||
---|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |||
Preterm (<37 wks) | 1,006 | 93.86 | 1.14 (1.01–1.28) | 0.03 | 1.10 (0.97–1.24) | 0.13 |
Extremely preterm (22–27 wks) | 19 | 123.62 | 1.61 (0.75–3.45) | 0.22 | 1.46 (0.68–3.15) | 0.33 |
Very preterm (28–33 wks) | 203 | 101.91 | 1.15 (0.90–1.48) | 0.25 | 1.09 (0.85–1.40) | 0.49 |
Late preterm (34–36 wks) | 784 | 91.45 | 1.12 (0.99–1.28) | 0.08 | 1.09 (0.96–1.24) | 0.19 |
Early term (37–38 wks) | 3,077 | 78.97 | 1.10 (1.03–1.18) | 0.005 | 1.06 (0.98–1.13) | 0.13 |
Full term (39–41 wks) | 12,413 | 74.31 | Reference | Reference | ||
Post term (≥42 wks) | 2,004 | 82.57 | 0.97 (0.89–1.05) | 0.41 | 1.02 (0.93–1.11) | 0.69 |
Per additional 5 weeks (trend) | 0.86 (0.80–0.93) | <0.001 | 0.93 (0.86–1.00) | 0.05 |
aIncidence rate per 100,000 person-years.
bAdjusted for shared familial (genetic and/or environmental) factors.
cAdditionally adjusted for specific child characteristics (birth year, sex, birth order) and maternal characteristics (age, education, birth country or region, body mass index, history of lipid disorder).
Abbreviations: HR, hazard ratio