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. 2019 Apr 30;25(11):1828–1837. doi: 10.1093/ibd/izz081

Table 3.

Risk of Disease-Related Complications Comparing Patients With Early Proactive, Reactive, and No Monitoring in Subcohort With 12 Months of Data Between Enrollment and Biologic Initiation and Only Endoscopy-Based Monitoring Used for Assessment of Mucosal Inflammation

No Early Endoscopy Early Proactive Endoscopy vs No Early Endoscopy Early Reactive Endoscopy vs No Early Endoscopy Early Reactive Endoscopy vs Proactive Endoscopy
IR (95% CI), per 100 Person-Years aHR (95% CI) P aHR (95% CI) P aHR (95% CI) aHR (95% CI)
Crohn’s disease
Corticosteroid use 58.4 (56.2–60.8) 0.82 (0.75–0.89) <0.01 1.10 (1.01–1.21) 0.03 1.35 (1.20–1.51) <0.01
Changed biologic 34.3 (32.9–35.9) 0.97 (0.89–1.06) 0.52 0.99 (0.90–1.10) 0.88 1.02 (0.90–1.15) 0.73
Hospitalization 23.6 (22.3–25.0) 0.85 (0.75–0.95) <0.01 1.38 (1.23–1.54) <0.01 1.63 (1.40–1.89) <0.01
Surgery 5.3 (4.7–5.9) 0.73 (0.57–0.93) 0.01 1.08 (0.86–1.36) 0.49 1.48 (1.09–2.02) 0.01
Overall 103.3 (99.4–107.4) 0.87 (0.80–0.95) <0.01 1.13 (1.04–1.23) <0.01 1.29 (1.16–1.44) <0.01
Ulcerative colitis
Corticosteroid use 72.0 (67.9–76.4) 0.76 (0.67–0.86) <0.01 0.88 (0.78–1.00) 0.04 1.16 (1.00–1.35) 0.05
Changed biologic 31.4 (29.3–33.7) 0.96 (0.83–1.10) 0.53 0.76 (0.65–0.88) <0.01 0.79 (0.66–0.94) <0.01
Hospitalization 19.0 (17.2–20.9) 1.09 (0.91–1.32) 0.97 2.17 (1.86–2.53) <0.01 1.98 (1.62–2.42) <0.01
Surgery 1.9 (1.4–2.5) 1.79 (1.12–2.87) 0.02 4.20 (2.89–6.11) <0.01 2.34 (1.50–3.67) <0.01
Overall 118.1 (111.5–125.1) 0.86 (0.76–0.96) <0.01 1.13 (1.01–1.26) 0.04 1.32 (1.14–1.51) <0.01

Abbreviation: IR, incidence rate.