Table 3.
No Early Endoscopy | Early Proactive Endoscopy vs No Early Endoscopy | Early Reactive Endoscopy vs No Early Endoscopy | Early Reactive Endoscopy vs Proactive Endoscopy | ||||
---|---|---|---|---|---|---|---|
IR (95% CI), per 100 Person-Years | aHR (95% CI) | P | aHR (95% CI) | P | aHR (95% CI) | aHR (95% CI) | |
Crohn’s disease | |||||||
Corticosteroid use | 58.4 (56.2–60.8) | 0.82 (0.75–0.89) | <0.01 | 1.10 (1.01–1.21) | 0.03 | 1.35 (1.20–1.51) | <0.01 |
Changed biologic | 34.3 (32.9–35.9) | 0.97 (0.89–1.06) | 0.52 | 0.99 (0.90–1.10) | 0.88 | 1.02 (0.90–1.15) | 0.73 |
Hospitalization | 23.6 (22.3–25.0) | 0.85 (0.75–0.95) | <0.01 | 1.38 (1.23–1.54) | <0.01 | 1.63 (1.40–1.89) | <0.01 |
Surgery | 5.3 (4.7–5.9) | 0.73 (0.57–0.93) | 0.01 | 1.08 (0.86–1.36) | 0.49 | 1.48 (1.09–2.02) | 0.01 |
Overall | 103.3 (99.4–107.4) | 0.87 (0.80–0.95) | <0.01 | 1.13 (1.04–1.23) | <0.01 | 1.29 (1.16–1.44) | <0.01 |
Ulcerative colitis | |||||||
Corticosteroid use | 72.0 (67.9–76.4) | 0.76 (0.67–0.86) | <0.01 | 0.88 (0.78–1.00) | 0.04 | 1.16 (1.00–1.35) | 0.05 |
Changed biologic | 31.4 (29.3–33.7) | 0.96 (0.83–1.10) | 0.53 | 0.76 (0.65–0.88) | <0.01 | 0.79 (0.66–0.94) | <0.01 |
Hospitalization | 19.0 (17.2–20.9) | 1.09 (0.91–1.32) | 0.97 | 2.17 (1.86–2.53) | <0.01 | 1.98 (1.62–2.42) | <0.01 |
Surgery | 1.9 (1.4–2.5) | 1.79 (1.12–2.87) | 0.02 | 4.20 (2.89–6.11) | <0.01 | 2.34 (1.50–3.67) | <0.01 |
Overall | 118.1 (111.5–125.1) | 0.86 (0.76–0.96) | <0.01 | 1.13 (1.01–1.26) | 0.04 | 1.32 (1.14–1.51) | <0.01 |
Abbreviation: IR, incidence rate.