Appendix 1—figure 3. Another schematic summarizing our circuit model, including predictions for cH ablation and activation results.

Here, the proposed mutual inhibition between cH and LH activity is represented by a ‘see-saw’, and relevant inputs/outputs during each phase are represented by ‘forces’. We represent our predictions for what happens when the cH is ablated, as well as when it is activated in the presence of food, for both satiated and hungry fish. We assume that the effects of priming are weaker than the effects of acute mutual inhibition. Color codes are consistent with Figure 2. Note that activation of the cH prior to feeding is not depicted in this diagram: in this scenario we predict that this would cause priming of the LH that increases subsequent feeding, the effect of which may be more obvious in satiated fish where cH activity starts off lower (consistent with our optogenetics results).