Table 2.
Comparison of Outcomes in the CD34+ Cell-Selected and Unmodified Grafts
| Outcome | CD34+ Cell-Selected MAC, % (95% CI) | Unmodified RIC, % (95% CI) | P Value |
|---|---|---|---|
| RFS | |||
| 1 year | 68.1 (61.3–74) | 61 (52.8–68.3) | .13 |
| 3 years | 54.9 (47.6–61.7) | 50.4 (42–58.3) | |
| OS | |||
| 1 year | 74 (67.4–79.5) | 68.3 (60.2–75.1) | .285 |
| 3 years | 57.9 (50.5–64.6) | 56.2 (47.7–63.9) | |
| Relapse incidence | |||
| 1 year | 13.7 (9–18.5) | 27.7 (20.6–34.9) | .001 |
| 3 years | 19.1 (13.6–24.6) | 33.1 (25.4–40.8) | |
| NRM | |||
| 100 days | 9.3 (5.3–13.3) | 3.9 (.8–7.1) | .106 |
| 1 year | 18.1 (12.8–23.4) | 11.3 (6.2–16.3) | |
| 3 years | 25.9 (19.7–32.1) | 16.5 (10.4–22.6) | |
| Acute GVHD grade II-IV | |||
| 180 days | 17.6 (12.4–22.9) | 46.1 (38.1–54.1) | <.001 |
| Chronic GVHD | |||
| 3 years | 6 (2.7–9.4) | 55.3 (47.1–63.4) | <.001 |
| CRFS | |||
| 1 year | 64.7 (57.7–70.8) | 21.3 (15.1–28.1) | <.001 |
| 3 years | 51.1 (43.8–57.9) | 7.4 (3.8–12.6) |