Table 5.
Multivariate Analysis Model of Risk Factors for Transplantation Outcomes in All Patients, Including the Merged Category of HCT Approach and Comorbidity Burden
| Patient and Graft Characteristic | NRM | Relapse | OS | CRFS | RFS | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | |
| Age (years) | .055 | .225 | .005 | .025 | .003 | |||||
| 50–59 | Reference | Reference | Reference | Reference | Reference | |||||
| >60 | 1.54 (.99–2.41) | 1.31 (.85–2.03) | 1.6 (1.16–2.22) | 1.34 (1.04–1.74) | 1.61 (1.18–2.19) | |||||
| Donor | .036 | .694 | .066 | .169 | .081 | |||||
| Related | Reference | Reference | Reference | Reference | Reference | |||||
| Nonrelated | 1.61 (1.03–2.52) | .95 (.59–1.41) | 1.37 (.98–1.9) | 1.2 (.92–1.57) | 1.32 (.97–1.81) | |||||
| Diagnosis | .023 | |||||||||
| AML | Reference | |||||||||
| MDS | 1.64 (1.07–2.5) | |||||||||
| DRI | - | - | <.001 | <.001 | <.001 | <.001 | ||||
| Low/intermediate | Reference | Reference | Reference | Reference | ||||||
| High | 3.33 (2.15–5.18) | 2.22 (1.58–3.14) | 1.94 (1.44–2.6) | 2.3 (1.65–3.19) | ||||||
| HCT approach and HCT-CI | .270 | .018 | .087 | <.001 | .047 | |||||
| TCD and HCT-CI 0–2 | Reference | Reference | Reference | Reference | Reference | |||||
| TCD and HCT-CI ≥ 3 | 1.57 (.9–2.75) | 1.32 (.75–2.34) | 1.49 (.96–2.29) | 1.53 (1.03–2.27) | 1.53 (1.02–2.3) | |||||
| RIC and HCT-CI 0–2 | .95 (.49–1.85) | 2.35 (1.31–4.2) | 1.66 (1.05–2.63) | 4.44 (3.03–6.53) | 1.71 (1.11–2.66) | |||||
| RIC and HCT-CI ≥ 3 | 1.21 (.59–2.47) | 2.13 (1.12–4.04) | 1.81 (1.09–2.99) | 5.05 (3.3–7.71) | 1.82 (1.13-2.94) | |||||