Table 2. Expression and function in human hematopoietic cells of selected genes implicated in JIA.
Data reflect mRNA and reflect approximate relative expression as extracted manually from human gene expression data (D-Map and Garvan) of at www.ImmGen.org (version May 2019).
| CD4 T | CD8 T | B | DC | NK | Monocyte | Neutrophil | Selected functions | |
|---|---|---|---|---|---|---|---|---|
| TYK2 | X | X | XX | XX | XX | XX | XX | Signal transduction for cytokines including type 1IFN, IL-6, IL-23 |
| SH2B3 | X | X | X | XX | XX | XX | X | Negative regulator of signals from TNF and growth factors (a.k.a. LNK) |
| LTBR | XX | X | XX | XX | Receptor for lymphotoxin and LIGHT | |||
| ERAP2 | XX | XX | XX | X | XX | X | X | antigen trimming for presentation by MHC I (a.k.a. LRAP) |
| STAT4 | XXX | XXX | X | XXX | XX | Signal transduction, Th1 differentiation | ||
| PTPN2 | XX | XXX | XX | XX | XXX | XX | XX | phosphatase, negative regulator of JAKs and other signaling molecules |
| IL2RA | XX | X | X | X | X | IL-2 receptor alpha chain (a.k.a. CD25) | ||
| IL2RB | XX | XX | XXX | XX | IL-2 receptor beta chain | |||
| ZFP36L1 | XX | XX | XXX | XX | XX | XXX | XXXX | Regulate mRNA stabilty, impacting lineages incuding B cells and chondrocytes |
| PRR5L | X | XX | XX | XX | mTORC2 regulation, fibroblast migration |