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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Adv Biol Regul. 2018 Dec 13;71:219–223. doi: 10.1016/j.jbior.2018.12.002

Figure 1. MiR-15/16, BCL2 and ROR1 in CLL.

Figure 1.

In normal B-cells miR-15/16 inhibit ROR1 and BCL2. In CLL cells miR-15/16 is deleted, ROR1 and BCL2 are overexpressed causing B-cell transformation.