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. Author manuscript; available in PMC: 2020 Jul 2.
Published in final edited form as: Kidney Blood Press Res. 2019 Jul 2;44(4):513–532. doi: 10.1159/000500457

Fig. 1.

Fig. 1.

Rac1 Inhibition prevented L-Hcy-induced NLRP3 inflammasome formation in podocytes. a Rac1 activity in UTP- and NSC23766-treated podocytes (n = 3). b and c Confocal images showing the colocalization of NLRP3 (green) with ASC (red; b) and NLRP3 (green) with caspase-1 (red; c) in cultured podocytes treated with UTP or NSC. d and e Summarized data showing the fold change in correlation coefficient (n = 6). * p < 0.05 versus Ctrl; # p < 0.05 versus Vehl/Ctrl; + p < 0.05 versus Vehl/L-Hcy. Vehl, vehicle; UTP, uridine triphosphate; NSC, NSC-23766; Hcy, homocysteine; NLRP3, NOD-like receptor containing pyrin domain 3; Ctrl, control.