. Author manuscript; available in PMC: 2020 Jan 3.

Published in final edited form as: Curr Top Dev Biol. 2019 Jan 3;133:49–90. doi: 10.1016/bs.ctdb.2018.11.018

Table 2:

Proteins Involved in Important Signaling Pathways during Sclerotome Specification

Protein Name^a	Abbreviation^a	Protein Fucntion^a	Skeletal Disorders^bc
Forkhead Box C2	F0XC2 (MFH1)	Forkhead family transcription factor	n/a
Gremlin	GREM1	BMP antagonist	Sclerosteosis, OMIM #269500
Noggin	NOG	BMP inhibitor	Multiple synostoses syndrome 1, OMIM #186500
NK3 Homeobox 2	NXK3.2 (BAXP1)	Transcriptional repressor	Spondylo-megaepiphyseal-metaphyseal dysplasia, OMIM #613330
Paired Box 1	PAX1	PAX family transcription factor	Otofaciocervica syndrome 2, OMIM #615560; Klippel-feil syndrome, OMIM #613702; Diaphanospondyiodysostosis, OMIM #608022
Paired Box 9	PAX9	PAX family transcription factor	Tooth agenesis, OMIM #604625
Sonic Hedgehog	SHH	Secreted ligand	Laurin-Sandrow syndrome, OMIM #135750; Hypoplasia or aplasia of tibia with polydactyly, OMIM #188740; Solitary median maxillary central incisor, OMIM #147250