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. Author manuscript; available in PMC: 2019 Oct 18.
Published in final edited form as: Cardiovasc Ther. 2018 Aug 22;36(5):e12462. doi: 10.1111/1755-5922.12462

FIGURE 2.

FIGURE 2

CA improves chronotropic response to catecholamine and enhances whole body oxygen consumption during exercise: (A) shows change in heart rate after intraperitoneal injection of 20 mcg/kg of single dose of isoprenaline. Note significant higher response to catecholamine as evidenced by a higher change in heart rate postisoprenaline. (B) denotes time taken by the mouse to get exhausted on the treadmill. Although the exhaustion times were comparable, there was a significant increase in VO2 (oxygen consumed-a surrogate marker for cardiac output at peak of exercise and decrease in respiratory exchange ratio during peak exercise in CA fed mice compared to chow fed mice (C)). n = 5 per group; Results: Mean ± SD for A and B, SEM for C; *P < 0.05; Stats: t test for A and B. Mann–Whitney across time-points for C