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Possible unbinding pathways of etoposide from human Topoisomerase II. Below mode: Etoposide unbinds via the C-gate of TopoII. Center mode: Etoposide unbinds through the dimer intersection. Side mode: Unbinding occurs from the side of the monomer to which the drug molecule is bound. The modes are defined based on the direction of unbinding, relative to the enzyme structure. Color Code: DNA (pink), TopoII (white), Etoposide (blue); black arrows show the direction of unbinding.
