TABLE II.
Top 10 important microstate state conformational changes for transition between microstates 3 and 8, as well as between metastable states 1 and 2. a
| Transition from | Transition from | |||
|---|---|---|---|---|
| Top 10 conformational | metastable state 1 | metastable state 2 | ||
| changes decreased | Transition from | Transition from | (dark state) to | (light state) to |
| effective reaction rate | microstate 3 to | microstate 8 to | metastable state 2 | metastable state 1 |
| for certain transition | microstate 8 | microstate 3 | (light state) | (dark state) |
| 1 | 1:17 b (23.042%) c | 1:17 (23.042%) | 1:17 (22.226%) | 1:17 (26.302%) |
| 2 | 3:17 (17.747%) | 3:17 (17.747%) | 7:21 (19.179%) | 2:17 (18.477%) |
| 3 | 7:21 (17.656%) | 7:21 (17.656%) | 3:17 (17.013%) | 7:21 (18.201%) |
| 4 | 8:20 (16.792%) | 8:20 (16.792%) | 2:17 (15.437%) | 8:20 (17.305%) |
| 5 | 2:17 (16.054%) | 2:17 (16.054%) | 8:20 (12.665%) | 3:17 (13.752%) |
| 6 | 4:17 (9.309%) | 4:17 (9.309%) | 4:17 (8.912%) | 4:17 (9.619%) |
| 7 | 17:33 (8.740%) | 17:33 (8.740%) | 17:33 (7.757%) | 17:33 (9.035%) |
| 8 | 3:4 (5.440%) | 3:4 (5.440%) | 3:4 (5.138%) | 8:33 (5.289%) |
| 9 | 8:33 (5.108%) | 8:33 (5.108%) | 6:7 (4.319%) | 17:21 (4.186%) |
| 10 | 17:21 (4.044%) | 17:21 (4.044%) | 17:21 (4.178%) | 17:20 (3.966%) |
a
Numbers in bold indicate the edges with importance higher than 10%.
b
The edge representing microstate transition between microstates A and B (A:B).
c
The importance of a target edge as the decrease in effective reaction rate constant in the DKTN model after removing that edge comparing with the original DKTN model.