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. 2019 Oct 14;8:29–41. doi: 10.2147/ITT.S219867

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© 2019 Muhammad et al.

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DMF or MMF treatment impairs LPS-activated conversion of procaspase-1 to caspase-1 in NK92 cells. (A) Treatment of NK92 cells with 10 μg/mL LPS for 24 h induced the conversion of procaspase-1 (45kDa) into cleaved subunits of active caspase-1 (22kDa and 12kDa, respectively). Combined treatment of LPS with DMF or MMF showed a reduction in the conversion of procaspase-1 into cleaved active-caspase-1. NK92 cells treated with100 μM DMF or MMF did not induce this conversion. (B) Densitometry calculation of the conversion of procaspase-1 into caspase-1. Actin was used as an internal control.