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. 2019 Oct 16;6(5):ENEURO.0165-19.2019. doi: 10.1523/ENEURO.0165-19.2019

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Copyright © 2019 Sun et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 2. — SD between ZT0 and ZT4 disturbed acquisition of extinction but not locomotion, anxiety or motivation behavior. A, Treatment groups and procedure. Contextual fear conditioning was performed 1 d before SD, which was conducted between ZT0 and ZT4 (top). Contextual fear conditioning was performed 1 d before SD, which was conducted between ZT4 and ZT8 (middle). SD, which was performed between ZT0 and ZT4, was conducted 1 d before fear conditioning (bottom). Test and time signs indicated the time-points for fear extinction training following acquisition of fear conditioning. B, A similar effect was observed between pre-SD(0–4) and control groups in freezing levels during acquisition of fear conditioning; n = 12 for each group. C, Fear extinction learning between SD and CON groups in Post-COND SD(0–4) and SD(4–8), and Pre-COND SD conditions; ***p < 0.001; n = 5–8 per test. D, Rats were SD between ZT0 and ZT4, and tested at ZT4 on the next day. Locomotion was defined as total travel distance in an open field, and anxiety was defined as percentage time in the center of the apparatus. For motivation, rats were placed in the testing chamber and allowed to press for food on a FR-60 schedule of reinforcement. SD did not significant affect travel distance (E), the percentage time spent in the center of the apparatus (F), and press time per min in the test chamber (G); n = 8 per group.