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. 2019 Oct 1;116(42):20953–20958. doi: 10.1073/pnas.1909557116

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Copyright © 2019 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — Clinical response to hydralazine varies by time of administration. (A) The 5,481 doses of IV hydralazine ranging from 0.1 to 0.2 mg/kg body weight. (B) Median response to hydralazine in diastolic BP (DBP) and systolic BP (SBP) as a function of dosing time. Response was computed as the percent change between dosing BP (just before dose) and mean BP over the 3 h following each dose (Methods). Tukey’s post hoc pairwise tests between all 2-h time bins detected strongest differences between 10:00 PM and 12:00 AM versus 6:00 AM to 8:00 AM, 8:00 AM to 10:00 AM, 2:00 PM to 4:00 PM, and 4:00 PM to 6:00 PM (Dataset S2).