Table 3.
Association of gap between brain age and chronological age with incident dementia assessed by logistic regression and Cox proportional hazards models, both in the total study sample and in a subsample with a minimum follow-up time of 5 years
| Logistic regression | Cox regression | |||||
| Model | n/N | OR (95% CI) | P value | n/N | HR (95% CI) | P value |
| Total sample | ||||||
| Model I | 159/1808 | 1.15 (1.10–1.20) | 2.66 × 10−10 | 159/1808 | 1.15 (1.11–1.20) | 1.02 × 10−12 |
| Model II | 154/1790 | 1.09 (1.04–1.14) | 4.77 × 10−4 | 154/1790 | 1.09 (1.05–1.15) | 2.27 × 10−5 |
| Model III | 150/1714 | 1.09 (1.04–1.14) | 7.97 × 10−4 | 150/1714 | 1.09 (1.04–1.14) | 9.62 × 10−5 |
| Sample follow-up time >5 y | ||||||
| Model I | 62/1366 | 1.11 (1.04–1.18) | 1.26 × 10−3 | 62/1366 | 1.13 (1.06–1.20) | 1.38 × 10−4 |
| Model II | 60/1352 | 1.08 (1.01–1.16) | 2.48 × 10−2 | 60/1352 | 1.10 (1.02–1.17) | 7.58 × 10−3 |
| Model III | 58/1305 | 1.08 (1.01–1.16) | 3.38 × 10−2 | 58/1305 | 1.09 (1.01–1.16) | 1.78 × 10−2 |
Model I: age + sex.
Model II: model I + GM volume + ICV + hippocampal volume + WMH volume.
Model III: model II + years of education + APOE ε4 carrier status.
CI; OR; HR; number of cases (n); total number of participants (N).