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Pressure-dependent protein stability from NMR measurements. (A) Backbone ribbon representation of L99A T4L (PDB ID code 1L90). The gray space-filling shapes represent the hydrated, hydrophilic (1 and 2), and empty, hydrophobic cavities (3 and 4) in the structure. (B) Residue-specific stabilities determined as a function of pressure with native-state HX, shown for selected amide hydrogens (colored symbols). The lines represent fits to Eqs. 1 and 2 in the text.
