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. 2019 Sep 5;116(42):21191–21197. doi: 10.1073/pnas.1903763116

Fig. 1.

Fig. 1.

SCAR/WAVE regulates ASM forgetting in the MB neurons. (A) Memory retention curves. SCAR-RNAi-expressing flies (RU486+) showed slower memory decay compared with uninduced control. n = 8. (B) SCAR knockdown increased 3-h memory without affecting ARM component (3 hARM). Lightning symbol represents electric shock reinforcement. n = 8. (C) Interference-based forgetting was suppressed by RU486-induced expression of SCAR-RNAi. n = 8. (D and E) Memory performance in flies with SCAR knockdown (D) and overexpression (E) in the adult MB neurons. n = 8. (F) Effect of RNAi knockdown of different members in the SCAR complex on 3-h memory. n = 8. (G) RNAi knockdown of SCAR dominated the effect of constitutively active Rac1 (Rac1-CA) on 4 h memory. Rac1-CA-expressing flies (yellow bar, RU486+) had lower memory performance. Flies with coexpression of both Rac1-CA and SCAR-RNAi (orange bar, RU486+) showed memory performance higher than controls, and the performance was not different from flies expressing SCAR-RNAi alone. n = 8 to 12. (H) Data summary. Data are means ± SEM. *P < 0.05. n.s., nonsignificant.