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. 2019 Sep 30;116(42):21166–21175. doi: 10.1073/pnas.1913803116

Fig. 2.

Fig. 2.

Phylogenomic analysis of CcoG-like proteins in bacteria. (A) Sequence similarity network of proteins in the UniProt database that contain both the 4Fe-4S ferredoxin-type Fe-S–binding domains Fer4_5 (PF12801) and Fer4_18 (PF13746) with and without the Ig-like FixG_C (PF11614) domain, and other proteins that contain the FixG_C domain (domain combinations are indicated in SI Appendix, Fig. S8 and Dataset S1). The nodes are colored based on proteobacterial class or if the corresponding organism is from Bacteroidetes. Protein clusters are numbered and correspond to the indicated clades in the tree in B. (B) Phylogenetic reconstruction of selected (Materials and Methods) CcoG-like proteins. Whether a CcoN homolog was detected in the corresponding proteome is indicated with a blue square. The presence of the corresponding ccoG-like gene in a neighborhood with genes encoding CcoN, CcoO, CcoP, CcoH, CcoI, CcoS, or CcoQ is indicated with a black box. Correspondence with the network in A is indicated by the numbers around the outside of the tree. (C) Treemaps illustrating the number of proteomes from each phylum with the indicated presence/absence of CcoN-like and CcoG-like proteins. The size of each treemap is scaled to the overall sum of proteomes for each category.