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. 2019 Sep 30;116(42):21236–21245. doi: 10.1073/pnas.1907511116

Fig. 3.

Fig. 3.

Aloperine is a KCNQ-dependent vasorelaxant. All error bars indicate SEM. (A) Exemplar myography recordings of the tension changes initiated by aloperine (at concentrations indicated) alone (control) or with linopirdine (3 µM) in rat mesenteric artery precontracted with 10 µM methoxamine. (B) Dose response for relaxation of methoxamine precontracted rat mesenteric artery by aloperine alone (control) or in the presence of linopirdine as indicated (n = 6 to 12). (C) Scatter plot showing aloperine logEC50 values for relaxation of methoxamine-precontracted rat mesenteric artery alone (control) or in the presence of linopirdine as indicated (n = 6 to 12; **P < 0.01 and ***P < 0.001).