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. 2019 Oct 1;26(10):915–930. doi: 10.5551/jat.48405

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2019 Japan Atherosclerosis Society

This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/3.0/

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Fig. 6. — Effects of rivaroxaban in cardiac myocytes in vitro

(A) Hypoxic stimulation induced a decrease in the cell viability of CMs. The cell viability of CMs under hypoxia was dose-dependently improved by the presence of rivaroxaban for 12 and 24 hours (n = 4–5 per group). (B) Hypoxic stimulation caused the apoptosis of CMs. The apoptotic CMs were reduced remarkably after rivaroxaban treatment for 24 hours. The ratio of TUNEL-positive cells/total cells (%) was calculated in 10 areas under a microscope and averaged. *p < 0.05, **p < 0.01, and ***p < 0.001. Riv: rivaroxaban.