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. 2019 Oct 1;26(10):915–930. doi: 10.5551/jat.48405

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2019 Japan Atherosclerosis Society

This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/3.0/

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Fig. 7. — Effects of rivaroxaban on PAR1, PAR2, and inflammation genes in cardiac myocytes

(A) The mRNA expression levels of PAR1 and PAR2 in CMs were increased after stimulation under hypoxia for 24 hours. Rivaroxaban treatment reduced both PAR1 and PAR2, and PAR2 significantly (n = 4–6 per group). (B) Protein levels of PAR2 in CMs showed no significant changes (n = 3–4 per group). (C) The mRNA expression levels of pro-inflammatory genes in CMs were decreased significantly (n = 3–4 per group). *p < 0.05 and ***p < 0.001. Riv: rivaroxaban.