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. 2019 Oct 18;9:14960. doi: 10.1038/s41598-019-51530-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo competition of [⁶⁸Ga]Ga-DO3A-S01-GCG in NHP. Maximum Intensity Projections (MIPs, summed 0–90 minutes) of all PET examinations in the study, ranked after ascending DO3A-S01-GCG peptide mass dose. (A) SUV quantification of the dynamic uptake for all PET examinations in the liver (B) and spleen (C). SUV_90min as endpoint for liver binding of [⁶⁸Ga]Ga-DO3A-S01-GCG was inversely proportional to the increase in co-injected DO3A-S01-GCG peptide mass dose. (D) There was a clear difference in liver binding, assessed as SUV_90min, between the groups with the lowest (<0.2 µg/kg) and highest (≥5 µg/kg) administered peptide mass doses. ****Indicate p < 0.001.