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. 2019 Oct 18;9:14991. doi: 10.1038/s41598-019-51457-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DNA methylation age studies. Results for metEPICVal samples according to: Chronological age versus DNAmAge by age groups (A); Age-acceleration differences versus chronological age (B); Boxplot for age-acceleration differences between BCO and BCVY (C). Analogous results for TCGA samples according to: Chronological age versus DNAmAge by age groups (D); Age-acceleration differences versus chronological age (E); Boxplot for age-acceleration difference values between BCO and BCVY (F). Normal breast tissue results: Chronological age versus DNAmAge by age groups (G); Age-acceleration differences versus chronological age (H); Comparison of age-acceleration difference values between cancer and normal tissues (I). Representation of chronological age versus DNAmAge by oestrogen receptor positive and negative for metEPICVal (J) and TCGA samples (K); Age-acceleration differences by oestrogen receptor status for metEPICVal and TCGA data sets (L). Correlation values (r) for chronological age and DNAmAge by age group are included in plot representation.