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. 2019 Oct 18;9:14991. doi: 10.1038/s41598-019-51457-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TCGA expression for genes regulated by significantly different methylated CpG sites and pathway enrichment analysis. Genes regulated by differently methylated CpG sites from global BCVY hypomethylation profile found in metEPICVal samples localized in promoters (A) and enhancers (B). Genes regulated by differently methylated CpG sites from distinctive BCVY hypermethylation signature found in metEPICVal samples localized to TFBS (C) and enhancers (D); Green dots represent genes regulated by hypomethylated CpG regulatory sites and red dots those regulated by hypermethylated CpG regulatory sites; Percentage of significant enriched signalling pathways associated to genes differently expressed and regulated by global hypomethylated CpG sites in BCVY (E) and regulated by distinctive CpG probes generally hypermethylated in BCVY (F). EMO: extracellular matrix organization; NOTCH: Signalling by NOTCH/NOTCH1; Cell-Cell: cell communication.