#	Searches
1	exp BREAST/
2	exp BREAST DISEASE/
3	(1 or 2) and exp NEOPLASM/
4	exp BREAST TUMOR/
5	exp BREAST CANCER/
6	exp BREAST CARCINOMA/
7	(breast* adj5 (neoplas* or cancer* or carcin* or tumo* or metasta* or malig*)).ti,ab.
8	or/3‐7
9	exp BISPHOSPHONIC ACID DERIVATIVE/
10	(diphosphonate* or diphosph#nate*).tw,kw,ot.
11	(bisphosph#nate* or biphosph#nate*).tw,kw,ot.
12	(diphosphonic* or bisphosphonic*).tw,kw,ot.
13	or/9‐12
14	ALENDRONIC ACID/
15	(alendronat* or aledronic*).tw,kw,ot.
16	(fosamax* or binosto* or adronat* or alendros* or onclast* or alend*).tw,kw.
17	or/14‐16
18	CLODRONIC ACID/
19	(clodronic* or clodronat*).tw,kw.
20	(bonefos* or clasteon* or difosfonal* or ossiten* or mebonat* or loron*).tw,kw.
21	Cl2MDP.tw,kw.
22	or/18‐21
23	ETIDRONIC ACID/
24	(etidronic* or etidronat*).tw.
25	(didronel* or xidifon* or dicalcium or xidiphon*).tw,kw.
26	(HEDP or EHDP).tw,kw.
27	or/23‐26
28	MEDRONATE TECHNETIUM TC 99M/
29	(medronat* or medronic*).tw,kw.
30	(Technetium adj2 Tc 99m adj2 Medronat*).tw,kw.
31	(Tc 99m MDP or Tc MDP).tw,kw.
32	or/28‐31
33	IBANDRONIC ACID/
34	(ibandronic* or ibandrovic* or ibandronat*).tw,kw.
35	(bon?iva* or bondronat* or adronil*).tw,kw.
36	(RPR102289A or RPR‐102289A).tw,kw.
37	(BM210955 or BM‐210955).tw,kw.
38	or/33‐37
39	PAMIDRONIC ACID/
40	(pamidro* or pamidronic* or amidronat*).tw,kw.
41	or/39‐40
42	RISEDRONIC ACID/
43	(risedronic* or risedronat*).tw,kw.
44	(actonel* or atelvia* or benet* or optinate*).tw,kw.
45	(NE58095 or NE‐58095).tw,kw.
46	(cgp 23339 or cgp23339 or cgp 23339a or cgp 23339a).tw,kw.
47	or/42‐46
48	ZOLEDRONIC ACID/
49	(zoledronic* or zoledronat*).tw,kw.
50	(zometa* or zomera* or aclasta* or reclast* or aredia* or orazol*).tw,kw.
51	(m05BA08 or CGP‐42446 or CGP42446 or CGP‐42446a or CGP42446a or zol‐446 or zol446).tw,kw.
52	or/48‐51
53	NERIDRONIC ACID/
54	(neridronat* or neridronic*).tw,kw.
55	(AHHexBP or 6AHHDP or 6‐AHHDP or nerixia).tw,kw.
56	or/53‐55
57	TILUDRONIC ACID/
58	(tiludronat* or tiludronic*).tw,kw.
59	(skelid* or tildren* or sr 42329 or sr42329 or sr 41319b or sr41319b).tw,kw.
60	or/57‐59
61	INCADRONIC ACID/
62	(incadronat* or incadronic*).tw,kw.
63	(cimadronat* or cimadronic*).tw,kw.
64	(bisphonal* or YM 175 or YM175).tw,kw.
65	or/61‐64
66	OLPADRONIC ACID/
67	(olpadronat* or olpadronic*).tw,kw.
68	(ig 8801 or ig8801).tw,kw.
69	or/66‐68
70	OSTEOCLAST DIFFERENTIATION FACTOR/
71	(osteoclast* adj2 differentiation factor*).tw,kw.
72	(osteoclast* adj2 ligand*).tw,kw.
73	(rank* adj3 ligand*).tw,kw.
74	((protein* adj2 RANKL) or (protein* adj2 TRANCE)).tw,kw.
75	tumor necrosis factor related activation induced cytokine.tw,kw.
76	or/70‐75
77	"RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B"/
78	((receptor activator* adj3 nf‐kappab) or (receptor activator* adj3 nuclear factor kappab)).tw,kw.
79	((receptor activator* adj3 nf‐kappa) or (receptor activator* adj3 nuclear factor kappa)).tw,kw.
80	tnfrsf11a.tw.
81	(trance r or trance receptor*).tw,kw.
82	or/77‐81
83	DENOSUMAB/
84	denosumab*.tw,kw.
85	(xgeva* or prolia*).tw,kw.
86	(AMG162 or AMG‐162).tw,kw.
87	or/83‐86
88	ROMOSOZUMAB/
89	(cdp 7851 or cdp7851).tw,kw.
90	(AMG 785 or AMG785).tw,kw.
91	evenity*.tw,kw.
92	or/88‐91
93	BLOSOZUMAB/
94	Blosozumab*.tw,kw.
95	(Ly2541546 or Ly 2541546).tw,kw.
96	or/93‐95
97	13 or 17 or 22 or 27 or 32 or 38 or 41 or 47 or 52 or 56 or 60 or 65 or 69 or 76 or 82 or 87 or 92 or 96
98	8 and 97
99	RANDOMIZED CONTROLLED TRIAL/
100	CONTROLLED CLINICAL STUDY/
101	random*.ti,ab.
102	RANDOMIZATION/
103	INTERMETHOD COMPARISON/
104	placebo.ti,ab.
105	(compare or compared or comparison).ti.
106	(open adj label).ti,ab.
107	((double or single or doubly or singly) adj (blind or blinded or blindly)).ti,ab.
108	DOUBLE BLIND PROCEDURE/
109	parallel group$1.ti,ab.
110	(crossover or cross over).ti,ab.
111	((assign$ or match or matched or allocation) adj5 (alternate or group$1 or intervention$1 or patient$1 or subject$1 or participant$1)).ti,ab.
112	(controlled adj7 (study or design or trial)).ti,ab.
113	(volunteer or volunteers).ti,ab.
114	trial.ti.
115	or/99‐114
116	8 and 97 and 115