Table 3.

Simulated steady-state tapentadol area under the curve in pediatric subjects receiving tapentadol every 4 hrs for 5 days

Age (years)	Simulated median steady-state AUC (ng· h/mL) (2.5th–97.5th percentile)
Dose: 1.0 mg/kg	Dose: 1.25 mg/kg	Dose: 1.5 mg/kg
12–<18	294.91 (186.61–450.55)	368.64 (233.27–563.19)	442.36 (279.91–675.83)
6–<12	247.48 (157.87–389.49)	309.34 (197.33–486.87)	371.21 (236.80–584.24)
2–<6	187.37 (118.60–306.58)	234.21 (148.25–383.23)	281.06 (177.90–459.87)

Abbreviation: AUC, area under the curve.