TSLNC8 inhibits autophagy by disrupting the IL-6/STAT3/HIF-1α pathway. The activities of IL-6, JAK2, HIF-1α, and p-STAT3 in A549 cells with or without CoCl2 were determined by Western blotting. GAPDH was used as an internal control. Each bar represents the mean ±SD calculated from 3 independent experiments. ## P<0.01, ### P<0.001 versus the pcDNA group. & P<0.05, && P<0.01, &&& P<0.001 versus the pcDNA+CoCl2 group.