Table 2.
Comparison of Demographic and Clinical Variables Among Study Participants With Different Aldosterone-Driver Mutation Status
| KCNJ5 (n = 24) | CACNA1D (n = 22) | ATP1A1 (n = 10) | ATP2B3 (n = 4) | P a | |
|---|---|---|---|---|---|
| Age, median (range), y | 49 (40–56) | 50 (44–58) | 53 (48–56) | 60 (55–69) | 0.13 |
| Male sex, no. (%) | 5 (21) | 19 (86) | 8 (80) | 4 (100) | <0.0001 |
| Race, no. (%) | 0.21 | ||||
| White | 19 (37) | 19 (37) | 10 (20) | 3 (6) | |
| Black | — | 2 (67) | — | 1 (33) | |
| Asian | 2 (100) | — | — | — | |
| LI | |||||
| Baseline | 32.6 (15.6–58.1) | 12.7 (5.2–21.7) | 5.5b (4.4–12.8) | 17.7 (11.0–58.1) | 0.006 |
| 20 Min | 14.7 (5.8–59.5) | 12.9 (8.4–24.8) | 12.7 (9.0–20.4) | 58.4 (21.3–182.2) | 0.51 |
| Contralateral index | |||||
| Baseline | 0.4 (0.3–0.6) | 0.4 (0.2–0.6) | 0.6 (0.3–2.6) | 0.4 (0.4–0.5) | 0.42 |
| 20 Min | 0.2 (0.1–0.5) | 0.2 (0.1–0.4) | 0.2 (0.2–0.3) | 0.2 (0.1–0.3) | 0.81 |
| Baseline hormonal concentrationc | |||||
| Aldo IVC | 37 (23–52) | 20 (13–38) | 27 (9–39) | 80 (37–201) | 0.04 |
| Aldo AVD | 2710 (881–4882) | 874 (223–2004) | 541b (242–1583) | 3267 (762–1234) | 0.01 |
| Aldo AVN | 59 (39–130) | 43 (21–74) | 91 (24–195) | 171 (65–271) | 0.36 |
| Cortisol IVC | 8 (6–10) | 7 (6–12) | 8 (5–10) | 11 (9–14) | 0.54 |
| Cortisol AVD | 42 (23–130) | 40 (22–78) | 27 (20–28) | 77 (26–137) | 0.47 |
| Cortisol AVN | 29 (21–90) | 46 (23–87) | 28 (19–57) | 51 (24–98) | 0.64 |
| 20-Min hormonal concentration after cosyntropin stimulation | |||||
| Aldo IVC | 51 (38–64) | 45 (31–62) | 59 (28–81) | 137 (39–267) | 0.63 |
| Aldo AVD | 8882 (3834–18561) | 9115 (4430–12900) | 9054 (5817–39800) | 20471 (11859–50854) | 0.27 |
| Aldo AVN | 481 (294–725) | 448 (271–1270) | 528 (299–881) | 533 (458–980) | 0.87 |
| Cortisol IVC | 18 (16–20) | 18 (16–21) | 18 (14–23) | 21 (18–24) | 0.60 |
| Cortisol AVD | 778 (638–1088) | 1356b (973–1481) | 1461b (868–1955) | 1111 (571–1781) | 0.02 |
| Cortisol AVN | 1043 (577–1360) | 1382 (757–1566) | 1391 (1350–1525) | 1397 (975–1768) | 0.13 |
Data are reported as median (interquartile range) unless otherwise indicated.
Abbreviations: aldo, aldosterone; AVD, dominant adrenal vein; AVN, nondominant adrenal vein.
a
Comparison across groups was performed by Kruskal–Wallis (P represents across group test) and Steel-Dwass all-pairs comparisons.
b
P < 0.05, compared with KCNJ5.
c
Aldosterone concentrations are shown in ng/dL and cortisol concentrations in µg/dL.