Table 3.
Comparison of Demographic and Clinical Characteristics of Patients With PA Across the Three Major Patterns of LI Response to Cosyntropin
| LI Response | P a | |||
|---|---|---|---|---|
| Ascending | Descending | Stable | ||
| No. of participants (%) | 60 (27) | 74 (33) | 88 (40) | |
| Age, median (range), y | 53 (44–62) | 51 (45–58) | 52 (47–61) | 0.48 |
| Male sex, % | 40 (67) | 37 (50) | 53 (60) | 0.14 |
| Race, no. (%) | 0.15 | |||
| White | 46 (29) | 46 (29) | 66 (42) | |
| Black | 12 (22) | 22 (42) | 19 (36) | |
| Asian | 1 (25) | 3 (75) | 0 | |
| Group, no. (%) | <0.0001 | |||
| U/U (n = 110) | 38 (34) | 37 (34) | 35 (32) | |
| U/B (n = 32) | 0 | 32 (100) | 0 | |
| B/U (n = 21) | 21 (100) | 0 | 0 | |
| B/B (n = 59) | 1 (2) | 5 (8) | 53 (90) | |
| LI, median (IQR) | ||||
| Baseline | 5.5b,c (2.5–15.3) | 16.2b (6.4–36.7) | 2.5 (1.4–9.2) | <0.0001 |
| 10 Min | 26.0b,c (8.6–77.9) | 4.8 (2.2–13.5) | 2.3 (1.6–10.8) | <0.0001 |
| 20 Min | 23.3b,c (8.8–72.6) | 4.0 (1.9–9.0) | 2.3 (1.6–8.6) | <0.0001 |
| Contralateral suppression index, median (IQR) | ||||
| Baseline | 0.5b (0.3–0.9) | 0.5b (0.3–1.5) | 1.6 (0.5–3) | 0.0002 |
| 10 Min | 0.2b,c (0.1–0.4) | 0.4 (0.2–1.1) | 0.6 (0.2–1.5) | <0.0001 |
| 20 Min | 0.2b,c (0.1–0.5) | 0.5 (0.2–1.2) | 0.7 (0.2–1.4) | <0.0001 |
| Baseline aldo IVC | 21 (13–38) | 21 (12–37) | 19 (12–36) | 0.70 |
| Baseline aldo AVD | 433c (131–1100) | 1235b (526–2930) | 522 (182–1405) | 0.0003 |
| Mutation (n = 61), no. | ||||
| KCNJ5 | 7 | 14 | 3 | |
| CACNA1D | 9 | 7 | 6 | |
| ATP1A1 | 5 | 2 | 3 | |
| ATP2B3 | 3 | 1 | — | |
| CTNNB1 | 1 | — | — | |
Abbreviations: aldo, aldosterone; AVD, dominant adrenal vein; IVC, inferior vena cava.
a
Comparison across groups was performed by Kruskal–Wallis (P represents across group test) and Steel-Dwass all-pairs comparisons.
b
P < 0.05, compared with stable LI.
c
P < 0.05, compared with descending LI.