Summary of findings 2. Piroxicam compared to indomethacin for assisted reproductive technology.
| Piroxicam compared to Indomethacin for assisted reproductive technology | ||||||
| Patient or population: assisted reproductive technology Setting: Clinic Intervention: Piroxicam Comparison: Indomethacin | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Risk with Indomethacin | Risk with Piroxicam | |||||
| Live birth | Not reported in any study | |||||
| Ongoing pregnancy | 200 per 1000 | 224 per 1000 (126 to 400) | RR 1.12 (0.63 to 2.00) | 170 (1 RCT) | ⊕⊝⊝⊝ VERY LOW 1 2 3 4 | |
| Miscarriage | 118 per 1000 | 118 per 1000 (52 to 268) | RR 1.00 (0.44 to 2.28) | 170 (1 RCT) | ⊕⊝⊝⊝ VERY LOW 1 2 3 4 | |
| Clinical pregnancy | 329 per 1000 | 352 per 1000 (234 to 537) | RR 1.07 (0.71 to 1.63) | 170 (1 RCT) | ⊕⊝⊝⊝ VERY LOW 1 2 3 | |
| Ectopic pregnancy | Not reported in any study | |||||
| Multiple pregnancy | Not reported in any study | |||||
| Side effects | Not reported in any study | |||||
| *The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; OR: Odds ratio | ||||||
| GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: Our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect Very low certainty: We have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect | ||||||
1 Downgraded 2 levels for very serious risk of bias including poor reporting of methods, attrition bias, selective reporting, and other biases.
2 Downgraded 2 levels for very serious indirectness
3 Downgraded 2 levels for very serious imprecision
4 Downgraded 1 level for large effect