Table 1.
High throughput screen identifying small molecule compounds that work in combination with CX-4945 to decrease MB growth. Individual treatments were compared to the combinatorial treatments of CX-4945 and the compound.
| Compound | Compound alone (% inhibition) |
Compound + CX-4945 (% inhibition) |
Activity |
|---|---|---|---|
| CX-4945 | 51.4 | N/A | Inhibitor |
| Temozolomide* | 48.1 | 74.3 | Inhibitor |
| Raltitrexed | 47.2 | 70.2 | Inhibitor |
| Flubendazole * | 61.4 | 68.1 | Inhibitor |
| Ptersotilbene | 22.0 | 59.4 | Weak inhibitor |
| Itavastatin Ca | 20.5 | 57.9 | Weak inhibitor |
*
Compound identified as an inhibitor again in duplicate screen