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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Pain. 2019 Nov;160(11):2473–2486. doi: 10.1097/j.pain.0000000000001648

Figure 2. NF1+/ex42del pigs show sexually dimorphic behaviors in response to thermal laser stimulation.

Figure 2.

(A) Schematic of site of thermal laser stimulation in pigs. (B) Male NF1+/ex42del pigs do not have enhanced response latency to thermal laser stimulation in comparison to wildtype pigs regardless of tumor presence at 12–15 months of age. (C) Female NF1+/ex42del pigs exhibit significantly reduced response latencies to thermal laser stimulation in comparison to wildtype pigs at several time points. Wildtype females become more sensitive to the laser stimuli over multiple testings, indicating perhaps testing fatigue and sensitization. (*p<0.05, ordinary two-way ANOVA, Fisher’s LSD test for each time point).