Table 1.
Baseline features of the DCIS cases
| Characteristic | DCIS-only (n=65) | DCIS+IBC (n=60) | Total (n=125) |
|---|---|---|---|
| Age at diagnosis (years) | |||
| Less than 40 | 10 (15%) | 11 (18%) | 21 (17%) |
| 40-49 | 19 (29%) | 15 (25%) | 34 (27%) |
| 50-64 | 23 (35%) | 23 (38%) | 46 (37%) |
| 65 and older | 13 (20%) | 11 (18%) | 24 (19%) |
| Race / ethnicity | |||
| NH Asian/Pacific Islander | 11 (17%) | 10 (17%) | 21 (17%) |
| NH white | 47 (72%) | 43 (72%) | 90 (72%) |
| Other | 6 (9%) | 4 (7%) | 10 (8%) |
| Surgery type | |||
| Lumpectomy | 27 (42%) | 21 (35%) | 48 (38%) |
| Mastectomy | 37 (57%) | 39 (65%) | 76 (61%) |
| No surgery | 1 (2%) | 0 | 1 (1%) |
| ER status† | |||
| Positive | 46 (71%) | 35 (58%) | 81 (65%) |
| Negative | 10 (15%) | 19 (32%) | 29 (23%) |
| Missing | 9 (14%) | 6 (10%) | 15 (12%) |
| HER2 status† | |||
| Positive | 15 (23%) | 12 (20%) | 27 (22%) |
| Negative | 37 (57%) | 35 (58%) | 72 (58%) |
| Missing | 13 (20%) | 13 (22%) | 26 (21%) |
| Tumor size (cm) | |||
| Median (range) | 2.4 (0.4-10.9) | 2.4 (0.7-13.0) | 2.4 (0.4-13.0) |
| Tumor margins | |||
| < 0.2 cm | 19 (29%) | 14 (23%) | 33 (26%) |
| 0.2 cm + | 46 (71%) | 44 (73%) | 90 (72%) |
| DCIS nuclear grade | |||
| Low | 5 (8%) | 2 (3%) | 7 (6%) |
| Intermediate | 22 (34%) | 16 (27%) | 38 (30%) |
| High | 38 (58%) | 39 (65%) | 77 (62%) |
| Copy number variations | |||
| None | 20 (31%) | 5 (8%) | 25 (20%) |
| Gene 1q only | 10 (15%) | 13 (22%) | 23 (18%) |
| Gene 8q24 only | 1 (2%) | 6 (10%) | 7 (6%) |
| Gene 11q13 only | 2 (3%) | 1 (2%) | 3 (2%) |
| Two of three gains | 10 (15%) | 20 (33%) | 30 (24%) |
| All three gains | 10 (15%) | 12 (20%) | 22 (18%) |
Note: DCIS = ductal carcinoma in situ; IBC = invasive breast cancer; NH = non-Hispanic.
†
Equivocal is included in the negative category.