Table 3:

Monte Carlo Simulation of Tumor Type^*

	CL (L/day)**	AUC (mcg*day/mL)**	Half-life β (days)**
Healthy volunteers	0.16 (0.12 – 0.21)	4,856 (3,717 - 6,426)	24.5 (19.2 – 33. 6)
Castleman’s Disease	0.27 (0.20 – 0.34)	2,884 (2,234 - 3,783)	19.1 (14.6 – 25.0)
Other tumor types	0.22 (0.17 – 0.28)	3,515 (2,786 – 4,627)	22.2 (17.5 – 30.5)

^*Simulations were conducted using a single dose of siltuximab at 11 mg/kg for a 70 kg patient with the average laboratory values from the study

^**Median (25-75% interquartile range)