Figure 1:

Neuroinflammation continuum. Neuroinflammation occurs in a continuum. It can result from acute phase injury where recovery to baseline occurs quickly after minor traumatic injury or infections, but when neuroinflammation is sustained, it has widely been associated with neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and multiple sclerosis (MS). In the middle of this neuroinflammation continuum are chronic sickness behavior disorders with no apparent underlying neurodegeneration (ME/CFS, GWI and chemobrain represent examples of distinct diseases in this non‐neurodegenerative category).