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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: J Physiol. 2019 Oct 1;597(20):5093–5108. doi: 10.1113/JP278279

Fig. 9. SLO2 KO mice are hypertensive and have a heightened response to vasoconstrictors.

Fig. 9.

Baseline systolic blood pressure (A), diastolic blood pressure (B), mean arterial pressure (C) and heart rate (D) of 3 month-old KCNT1 & KCNT2 double KO (SLO2 KO) and wild-type C57BL/6J mice. Systolic blood pressure was an average of 8.53±2.31 mmHg higher in SLO2 KO (105.1 mmHg) vs. WT mice (96.54 mmHg). Diastolic blood pressure was 5.01±2.02 mmHg greater in SLO2 KO (69.58 mmHg) vs. WT mice (64.57 mmHg), while mean arterial pressure was an average of 6.81±1.98 mmHg higher in SLO2 KO (81.42 mmHg) vs. WT mice (75.23 mmHg). Rise in systolic blood pressure (SBP) in response to acute intravenous administration of 1 μg/kg Ang II (E) or 100 μg/kg phenylephrine, PE (F) in SLO2 KO and wild-type mice. SBP increased by an average of 44.28 mmHg in SLO2 KO mice compared to 30.34 mmHg in WT mice in response to AngII. Phenylephrine resulted in an average SBP rise of 51.87 mmHg in SLO2 KO vs. 40.00 mmHg in WT mice. Data are presented as mean±SD. Student’s t-test was used to compare the 2 groups. *, P<0.05; **, P<0.01.