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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Anesth Analg. 2019 Nov;129(5):1365–1373. doi: 10.1213/ANE.0000000000004418

Figure 2. Spatial memory acquisition and recall with the Barnes Maze (P43).

Figure 2

A. Animals were trained during the acquisition of the Barnes maze task to find the escape box and escape latency was measured over the four separate trials on consecutive days. Two-way repeated measures ANOVA showed a significant decrease in latency over the four days (F (3,117) =10.2 p<0.001) but there was not a significant difference among groups. (Con/Sedentary n=9, Con/Exercise n=11, Iso/Sedentary n=10, Iso/Exercise n=14). B. Quadrant analysis of probe trial, 7 days after the last training session, showed all groups except the Iso/Sedentary animals spent significantly more time at the goal quadrant than chance (two-tailed one sample T-test, chance=25%). C. No significant difference in time exploring holes for Iso/Sedentary animals between the goal hole and the non-goal holes by Dunnett’s multiple comparisons test (p values adjusted for multiple comparisons). Con/Sedentary and Con/Exercise showed significant discrimination in the holes explored with holes +/− 4,8,9,10 and +/− 3,4,5,6,7,8,10 respectively. Exercise rescued the spatial memory in the Iso/Exercise group with ten significantly different holes. Error bars represent standard deviation. *p<0.05, **p<0.01, ***p<0.001