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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Anesth Analg. 2019 Nov;129(5):1365–1373. doi: 10.1213/ANE.0000000000004418

Figure 4. Barnes Maze acquisition and recall in mature adult (P112 cohort) is preserved.

Figure 4

A. Animals that previously underwent recognition memory battery and were naïve to the Barnes Maze learned the spatial location of the escape box over the course of four consecutive days as evidenced by a decrease in latency (two-way repeated measures ANOVA F (3,138) =12.27 p<0.001) (Con/Sedentary n=11, Con/Exercise n=12, Iso/Sedentary n=12, Iso/Exercise n=13). Like the P43 cohort, there was no difference in learning between groups. B. In the Probe trial, quadrant analysis showed discrimination of the goal with significant time spent in the goal quadrant compared to chance for all groups (two-tailed one sample T-test, chance=25%). C. The Con/Sedentary and the Con/Exercise groups had significant differences between the time spent exploring the goal hole vs every other space +/− from the goal by Dunnett’s multiple comparison test (p values adjusted for multiple comparisons). Different from the P43 cohort, the Iso/Sedentary P112 group spent significant differences in the goal compared to +/−4,5,6,7,8,9,10. Like the P43 cohort, the P112 Iso/Exercise group performed slightly better that than the Iso/sedentary group with differences +/−3,4,5,6,7,8,9,10. Error bars represent standard deviation. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001