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. 2019 Oct 15;12:8501–8513. doi: 10.2147/OTT.S208263

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© 2019 Lv et al.

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miR-761 decrease FGFR1 expression to impair OS cell growth in vivo via PI3K/Akt pathway. (A) The representative images of tumor xenografts obtained from agomir-NC and agomir-761 groups. (B) The growth curve for tumor volumes in tumor xenografts derived from agomir-NC and agomir-761 groups were determined on the basis of the tumor volume detected every 4 days for 4 weeks. *P<0.05 vs agomir-NC. (C) The weight of tumor xenografts was measured 4 weeks after injection. *P<0.05 vs agomir-NC. (D) Total RNA of tumor xenografts was extracted, and then used for the detection of miR-761 expression. *P<0.05 vs agomir-NC. (E) Total protein was isolated from tumor xenografts. The expression of FGFR1, p-PI3K, PI3K, p-Akt and Akt protein was detected via Western blot analysis.