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. 2019 Oct 7;2019:8130481. doi: 10.1155/2019/8130481

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Copyright © 2019 I-Cheng Chen et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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PolyQ aggregation and proteasome activity of SCA3-iPSC-derived neurons. (a) Filter trap assay was conducted with 1C2 antibody staining to detect the accumulation of polyQ aggregates. (b) SCA3-iPSC-derived neurons showed 1C2 staining-positive aggregates (green) and the aggregates colocalized with p62 (red) (white arrow). Scale bar: 50 μm. (c) Proteasome activity assay was performed to analyze UPS function in iPSC-derived neurons. NC-iPSC-derived neurons (NC-1 and NC-2) were normalized as 100%. Each experiment for each sample was performed in triplicate.