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. 2019 Oct 19;26:77. doi: 10.1186/s12929-019-0565-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Sodium diethyldithiocarbamate trihydrate (DETC) reduced TIC features and rescued the TMZ treatment effect. a Mice that received subcutaneous injection of the primary tumor GBM#1 in flank area were randomly treated with TMZ or TMZ/DETC everyday. The tumor growth was plotted in the left panel. Representative images of tumor size were also shown in the right panel. b The representative IHC staining of the specific protein were shown in the upper panel. The levels of the detected antigen labeling were analyzed and showed in the bar graphs (scale bar: 1000 μm). c The lysates of the GBM#1 tumor were collected with lysis buffer. The expression of the specific proteins were studied by western blotting and calculated for the density in the bar graph. d Mice that received brain injection of the primary tumor GBM#1 as orthotopic model were randomly treated with TMZ or TMZ/DETC consecutively. The survival data was plotted as the Kaplan-Meier curves shown in the plot. (*P < 0.05)