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. 2019 Apr 25;87(12):1165–1178. doi: 10.1002/prot.25697

Figure 9.

Figure 9

A successful ab initio modeling example (a domain of target T1000) for which no significant templates were identified. For the FM domain of T1000 (residues 282‐523), the accuracy of top L/5 predicted contacts is 100%, top L 79% and top 2L 50%. CONFOLD2 successfully built a complicated α‐helix + β‐sheet + α‐helix model for the domain with TM‐score of 0.8 and GDT‐TS of 0.64, while RosettaCon failed to generate a correct topology (ie, TM‐score = 0.33 < 0.5 threshold). This example shows that the pure contact distance driven method such as CONFOLD2 can build high‐quality structural models of complicated topology for large domains if a sufficient number of accurate contact predictions are provided