Table 1.

Traditional risk factors for individuals ages 44-54 in the high, intermediate, and low GRS groups. Mean and standard deviation are presented for continuous variables. Categorical variables are presented as percentages.

	High Genetic Risk (Q5)	Int Genetic Risk (Q2-Q4)	Low Genetic Risk (Q1)	p (High vs Low)
Age (years)	49.9 ± 3.0	49.8 ± 2.9	49.9 ± 2.7	0.86
Male (%)	46.8	47.1	47.2	0.97
BMI (kg/m2)	27.3 ± 5.6	28.9 ± 6.0	29.9 ± 5.8	2.9×10−10
Smoking (%)	16.4	19.5	19.9	0.26
Diabetes mellitus (%)	7.2	7.9	10.7	0.13
Systolic blood pressure (mmHg)	114.7 ± 17.7	117.0 ± 17.0	118.2 ± 17.7	0.007
Antihypertensive therapy (%)	17.9	20.9	23.1	0.093
Total cholesterol (mg/dl)	197.5 ± 36.8	194.6 ± 35.5	190.5 ± 36.8	0.010
LDL cholesterol (mg/dl)	121.2 ± 30.6	119.2 ± 30.2	115.6 ± 33.1	0.018
HDL cholesterol (mg/dl)	49.1 ± 13.8	49.9 ± 14.3	49.1 ± 13.5	0.996
Triglycerides (mg/dl)	136.7 ± 89.2	129.2 ± 95.9	131.3 ± 100.9	0.43
Statin (%)	7.0	6.8	4.8	0.27

Q5, quintile 5; BMI, body mass index, LDL, low density lipoprotein, HDL, high density lipoprotein.