Table 1.
Baseline demographic and clinical characteristics [mean (SD) or %] by group.
| CN (N=641) | MCI (N=569) | t, U, or χ2 | p | |
|---|---|---|---|---|
| Age | 73.63 (6.95) | 73.85 (7.09) | t=−0.54 | .589 |
| Education | 16.31 (2.69) | 15.89 (2.86) | t=2.66 | .008 |
| Female, % | 47.0% | 39.9% | χ2=57.71 | .017 |
| GDS | 1.16 (1.32) | 1.59 (1.42) | U=216,896.00 | <.001 |
| CDR=0/0.5,% | 54.1% / 45.7% | 12.3% / 87.5% | χ2=233.67 | <.001 |
| FAQ | 0.60 (1.16) | 3.85 (4.51) | U=271,001.00 | <.001 |
| Hachinski | 0.57 (0.66) | 0.69 (0.77) | U=169,161.50 | .015 |
| T2DM status*, % | 7.2% | 10.5% | χ2=4.01 | .045 |
| Aβ (pg/ml) | 1292.46 (621.24) | 942.92 (555.04) | t=8.71 | <.001 |
| t-tau (pg/ml) | 243.66 (98.15) | 300.85 (129.37) | t=−7.27 | <.001 |
| p-tau (pg/ml) | 22.44 (10.20) | 29.58 (14.70) | t=−8.22 | <.001 |
| APOE ε4+, % | 33.4% | 53.8% | χ2=51.15 | <.001 |
| MMSE | 28.69 (1.47) | 27.44 (1.84) | U=108,803.00 | <.001 |
| Logical Memory | 10.73 (4.27) | 5.32 (4.02) | t=21.97 | <.001 |
| AVLT Delayed Recall | 7.53 (3.75) | 2.50 (3.00) | t=25.89 | <.001 |
| AVLT Recognition | 27.30 (2.42) | 22.38 (3.90) | t=25.88 | <.001 |
| BNT | 28.15 (1.97) | 25.54 (3.97) | U=102,273.50 | <.001 |
| Animal Fluency | 20.62 (5.06) | 15.90 (4.84) | t=16.51 | <.001 |
| TMT Part A | 32.81 (9.64) | 45.47 (20.20) | U=263,723.00 | <.001 |
| TMT Part B | 82.13 (35.67) | 130.76 (71.13) | U=263,467.00 | <.001 |
CN=Cognitively Normal; MCI=Mild Cognitive Impairment; GDS=Geriatric Depression Scale; MMSE=Mini-Mental Status Exam; CDR=Clinical Dementia Rating; FAQ=Functional Activities Questionnaire; AVLT=Rey Auditory Verbal Learning Test; BNT=Boston Naming Test (30-item); TMT=Trail Making Test; Aβ=β-amyloid; t-tau=total tau; p=tau=hyperphosporylated tau; APOE=Apolipoprotein E. Sample size for cerebrospinal fluid biomarkers: CN n=363, MCI n=337.