Table 1.
Outline of Key Literature on Fibronectin
| Author | Year | Findings | Comment |
|---|---|---|---|
| Adachi et al. | 1998 | Fibroblasts grown in 3D culture produce more fibronectin, and connect fibronectin into more stable structures | This is an early example of 3D culture, which would be imperative to understand fibronectin networks |
| Zand et al. | 2003 | Cancer cells attached and grew more robustly on cellular fibronectin than plasma fibronectin. | Although plasma and cellular fibronectin are structurally similar, a few splice variants can dramatically affect how this molecule interacts with cancer |
| Missirlis et al. | 2017 | Removing cellular fibronectin stops fibroblast migration. The receptors responsible for persistent cell invasion and invasion speed are independent, suggesting that cellular fibronectin acts on many different receptors to achieve different effects on cellular behavior | This work again highlights that cellular fibronectin is a key component in invasion, but it also shows that knocking out individual receptors incompletely removes the effects of this molecule |
| Sadlonova et al. | 2009 | Non-cancer associated fibroblasts (NAFs) and cancer associated fibroblasts (CAFs) are genetically distinct and express different factors | Mirroring the physiologic differences between CAFs and NAFs, the genetic signatures of these cell types are distinct |
| Kojima et al. | 2010 | Signaling via TGF-β and SDF-1 converts stroma fibroblasts into CAFs | This paper proposes that CAFs can originate from the local stroma, although not thought to be the primary source of CAFs, this identifies the heterogenetity of their origin |
| Ishii et al. | 2003 | For late stage tumors, the majority of CAFs seem to originate from the Bone Marrow | Currently, the bone marrow is the favored origin for most CAFs |
| Jotzu et al. | 2010 | Tumor signaling can induce local adipocytes to transform into CAFs | This notes another possible source of CAFs |
| Direkze | 2004 | Similar conclusion as Ishii et al. | -- |
| Quante et al. | 2011 | Similar conclusion as Ishii et al. This team used a mouse tumor model and identified that CAFs within the neoplasm were from donor bone marrow. | -- |
| Erdogan et al. | 2017 | CAFs organize fibronectin to establish tracts for cancer invasion | Fibronectin has a direct role in promoting cancer cell invasion into the stroma |
| Attieh et al. | 2017 | Similar conclusion as Erdogan et al. | -- |
| Nicosia et al. | 1993 | Fibronectin leads budding blood vessels | Fibronectin helps form new blood vessels and could have a role in tumor angiogenesis |
| Gopal et al. | 2017 | Fibronectin networks layed down by head and neck squamous cell cancers is a component of cancer migration into the local stroma, the integrins vβ6 and α9β1 are essential in this process | This work highlights that the fibronectin scaffold is a driver in malignant invasion, but also that many integrins interact with this molecule |