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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Alzheimers Dement. 2019 Aug 12;15(10):1253–1263. doi: 10.1016/j.jalz.2019.06.3916

Figure 1. Neuronal Classification Using Double Staining Immunohistochemistry.

Figure 1.

The figure depicts an example of how the neurons were classified. (A) A neuron negative for p-tau and not expressing the neurotransmitter of interest (shown in purple); (B) a neuron positive for phospho-tau only (in brown); (C) a neuron positive for neurotransmitter only (in this case, orexin; in red); (D) a neuron positive for both phospho-tau and neurotransmitter of interest (orexin). This photo was taken from the lateral hypothalamic area from a case with Alzheimer’s disease. The black bar represents 100 μm.