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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Semin Diagn Pathol. 2019 Apr 16;37(2):104–109. doi: 10.1053/j.semdp.2019.04.003

Fig 1.

Fig 1.

HTLV-1 Genome. The integrated provirus utilizes the promoter in the 5’LTR to drive transcription. This results in an unspliced full length mRNA that serves as genomic DNA to be packaged into virions. It is also used as a template for translation of Gag, Gag-Pr (1 ribosomal frameshift), and Gag-Pr-Pol (2 ribosomal frameshifts) polyproteins. The single spliced mRNA encodes Env that is cleaved into SU and TM envelope proteins. Completely spliced mRNAs encode Tax and Rex. Four accessory protein, p27I, p12I, p13II, and p30II are produced by alternative splicing of ORFs I and II. The p8I protein is a proteolytic cleavage product from p12I. The HBZ proteins are produced from unspliced and spliced mRNAs encoded by minus strand transcripts. Reprinted with permission from Viral Zone58